Ask AI: Identify the molecular DNA lesion responsible for chromosomal aberrations

One of the major DNA lesions responsible for chromosomal aberrations is double-strand breaks (DSBs). DSBs are caused by both external agents, such as ionizing radiation and certain chemicals, as well as endogenous processes, such as DNA replication, recombination, and repair. Failure to repair or misrepair of DSBs can lead to chromosomal aberrations, such as deletions, inversions, translocations, and amplifications, which can result in genetic diseases and cancer. It is therefore important to ensure proper DNA repair mechanisms are in place in order to reduce the risk of chromosomal aberrations.