Ask AI: How does the presence of g alpha subunit cause resistance to thyroid hormone?

The presence of G-alpha subunit can cause resistance to thyroid hormone because it disrupts the normal signaling pathway of thyroid hormone in the body. The G-alpha subunit interacts with the receptors for thyroid hormone, leading to a reduction in the binding of thyroid hormone to the receptors, and subsequently, a decrease in the expression of genes that are controlled by thyroid hormone. This results in a state of reduced sensitivity to thyroid hormone, also known as thyroid hormone resistance. The condition can have various causes, including genetic mutations that alter the structure or function of the G-alpha subunit or the thyroid hormone receptor. Treatment may involve hormone replacement therapy or medications that target the altered signaling pathway.