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Question: explain AT8 antibody for staining neurofibrillary tau tangles.
AT8 is an antibody used to specifically recognize and stain phosphorylated tau protein, a major component of the neurofibrillary tangles found in Alzheimer's disease and other tauopathies. It recognizes tau proteins that are phosphorylated at Ser202/Thr205, which is a hallmark of tauopathy pathology. AT8 is a monoclonal antibody, meaning it is produced artificially in a lab and can be used to accurately and reliably detect tau expression and localization in cells and tissue samples. It is an important tool for detecting and understanding the cause of neurodegenerative diseases.
Jan. 18, 2023, 12:13 a.m.
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