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Question: Evaluate one cell-based therapeutic solution to engineer cartilage using research from the last two years.
One recent cell-based therapeutic solution to engineer cartilage involves the use of induced pluripotent stem cells (iPSCs). In a 2019 study, researchers found that iPSCs could be used to generate cartilage-like tissues in vitro through a two-step process of chondrogenic differentiation and tissue remodeling, with the added bonus of being non-invasive and patient-specific. Additionally, these tissues displayed several characteristics of native human cartilage, including the presence of proteoglycans, type II collagen, and an overall organized nanostructure. Researchers also demonstrated the potential of using these iPSC-derived tissues for cartilage regeneration in an in vivo model. This study provides strong evidence for using iPSCs as a tissue engineering solution for cartilage regeneration.
Jan. 5, 2023, 2:06 a.m.
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