Ask AI: Define FIVE key changes in genome-wide DNA methylation that occur during development.

1. An increase in methylation at regions responsible for regulating gene expression in early embryo development. 2. A decrease in methylation at key developmental genes in mid-embryo development, which allows them to be expressed. 3. A decrease in methylation at repetitive sequences, allowing for transposon and other transposable elements to be expressed. 4. An increase in methylation in specific genomic regions as a way to regulate tissue/organ specific gene expression during development. 5. An increase in methylation of promoter regions, which helps to regulate gene expression during development.