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Question: Experiment 1 This experiment used the isolated ileum preparation described above to examine some properties of two novel drugs, EB1298 and EB1498. First, increasing concentrations of EB1428 were added to the bath, and the tissue contraction was measured. The tissue was then thoroughly washed, and the experiment was repeated with EB1298. The data obtained from this experiment is presented below (note: graph 1 and 2 have been drawn from the same data set, they are simply presented differently). Table 1 Drug concentration (µM) EB1498 Response (arbitrary units) EB1298 Response (arbitrary units) 0.001 0 0 0.003 0 0 0.01 0 5 0.03 5 5 0.1 5 30 0.3 5 70 1 10 115 3 35 135 10 85 150 30 125 155 100 140 155 300 155 155 1. What is the key difference between these two graphs? 2. Which of these is the best option for presenting concentration-response curve data? Explain your answer. 3. Estimate the EC50 and Emax values for each of these two drugs. 4. What is the main pharmacological difference between these two drugs? Explain how you have reached this conclusion.
1. The key difference between the two graphs is that Graph 1 shows the response of both drugs EB1298 and EB1498, while Graph 2 shows only the response of EB1298. 2. Graph 2 is the best option for presenting concentration-response curve data because it clearly displays the concentration of the drug on the x-axis and the response on the y-axis, without any confusion of overlapping lines. 3. For EB1498, the EC50 is approximately 10 µM and the Emax is approximately 155 arbitrary units. For EB1298, the EC50 is approximately 1 µM and the Emax is approximately 155 arbitrary units. 4. The main pharmacological difference between these two drugs is in their potency, as seen from the difference in their EC50 values. EB1298 is more potent than EB1498, as it produces a response at a lower concentration. Additionally, both drugs reach a similar maximum response (Emax), indicating that they have a similar efficiency in producing a physiological response.
March 16, 2023, 6:06 a.m.
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